𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Thin-Layer Chromatographic Enantiomeric Resolution via Ligand Exchange

✍ Scribed by Dr. Kurt Günther; Dr. Jürgen Martens; Maren Schickedanz

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
128 KB
Volume
23
Category
Article
ISSN
0044-8249

No coin nor oath required. For personal study only.

✦ Synopsis

Using the plates thus impregnated, we have succeeded in performing thin-layer chromatographic enantiomeric resolution via ligand exchange: 2 pL of each of the racemic a-amino acids in Table 1 was applied as a 1% solution to the TLC plates and eluted with the given eluent (30-45 min). After drying, the spots were visualized using 0.1% ninhydrin reagent. The resolution of the enantiomers was so good that the respective antipodes could be determined at trace levels; the lowest level of detection was found to be 2 1%, although this value can probably be improved.

📜 SIMILAR VOLUMES

Direct enantiomeric resolution of some 2
Direct enantiomeric resolution of some 2-arylpropionic acids using (−)-brucine-impregnated thin-layer chromatography
✍ R. Bhushan; G. Thuku Thiongo 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 45 KB 👁 1 views

Direct enantioseparation of (AE)-ibuprofen and (AE)-flurbiprofen was achieved by two-dimensional thin-layer chromatography on silica gel plates impregnated with optically pure (À)-brucine as chiral selector. The solvent systems that were successful in resolving both the compounds were acetonitrile-m