✦ LIBER ✦

Direct enantiomeric resolution of some 2-arylpropionic acids using (−)-brucine-impregnated thin-layer chromatography

✍ Scribed by R. Bhushan; G. Thuku Thiongo

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 45 KB
Volume: 13
Category: Article
ISSN: 0269-3879
DOI: 10.1002/(sici)1099-0801(199906)13:4<276::aid-bmc843>3.0.co;2-m

No coin nor oath required. For personal study only.

✦ Synopsis

Direct enantioseparation of (AE)-ibuprofen and (AE)-flurbiprofen was achieved by two-dimensional thin-layer chromatography on silica gel plates impregnated with optically pure (À)-brucine as chiral selector. The solvent systems that were successful in resolving both the compounds were acetonitrile-methanol (16:3 v/v) for the first dimension and acetonitrile-methanolwater (16:3:0.4, v/v) for the second dimension. Iodine vapour was used for detection; the detection limit for both (AE)-ibuprofen and (AE)-flurbiprofen was 0.1 mg.

📜 SIMILAR VOLUMES

Thin layer chromatographic resolution of

Thin layer chromatographic resolution of some 2-arylpropionic acid enantiomers using L-(−)-serine, L-(−)-threonine and a mixture of L-(−)-serine and L-(−)-threonine-impregnated silica gel as stationary phases

✍ Hassan Y. Aboul-Enein; Mahmoud I. El-Awady; Charles M. Heard 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 94 KB 👁 1 views