Thienyl analogues of the alkaloids. Part II. 3-Thienyl analogues of ephedrine and ?-ephedrine
β Scribed by Barker, John M.; Huddleston, Patrick R.
- Book ID
- 119995269
- Publisher
- Royal Society of Chemistry
- Year
- 1973
- Weight
- 532 KB
- Volume
- 0
- Category
- Article
- ISSN
- 1472-7781
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π SIMILAR VOLUMES
The stereoselective syntheses of thienyl and furyl analogues of ephedrine starting from (R)-and (S)-cyanohydrins, respectively, are described. Addition of methyl Grignard to the O-trimethylsilyl protected optically active cyanohydrins (R)-and (S)-3 and hydrogenation of the resulting imino intermedia
Enzyme-Catalyzed Reactions. Part 27. Stereoselective Synthesis of Thienyl and Furyl Analogues of Ephedrine. -Title compounds of type (VII), potential vasodilators and bronchodilators, are stereoselectively prepared from enantiopure cyanohydrins (I). The latter are accessible by oxynitrilase catalyz