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Thiamine Hydrochloride—An Obligate Wheal Producing Agent1

✍ Scribed by Kalz, Frederick


Book ID
109872083
Publisher
Nature Publishing Group
Year
1942
Tongue
English
Weight
285 KB
Volume
5
Category
Article
ISSN
0022-202X

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An environmentally benign aqueous Biginelli protocol for the synthesis of substituted 3,4-dihydropyrimidin-2(1H)-ones using thiamine hydrochloride as a catalyst has been achieved. These ultrasound-assisted reactions proceed efficiently in water in the absence of organic solvent. Utilization of ultra