The pattern of nuclease degradation observed for an antisense phosphorothioate oligonucleotide in pig kidney was determined using liquid chromatography/electrospray mass spectrometry (LC/ESI-MS) and LC/ESI-MS/MS with a quadrupole ion trap mass spectrometer. Metabolites were separated by length using
Thermospray liquid chromatography—mass spectrometry with a quadrupole ion trap mass spectrometer
✍ Scribed by Raymond E. Kaiser Jr.; Jon D. Williams; Stephen A. Lammert; R. Graham Cooks; Don Zakett
- Publisher
- Elsevier Science
- Year
- 1991
- Weight
- 585 KB
- Volume
- 562
- Category
- Article
- ISSN
- 0378-4347
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract A new and simple ion source for thermospray on a sector field mass spectrometer has been designed, which is based on two sets of electrostatic quadrupole lenses to focus the divergent ion beam that emanates from the extraction cone into the ion source region. To illustrate the performan
Barbiturates are a class of drugs that are utilized as anesthetics and sleeping agents and are used for the treatment of anxiety, epilepsy and other psychiatric disorders. Because of their pyrimidine structures, barbiturates are highly basic compounds. The evaluation of the formation of adducts invo