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Thermosensitization of tumors by lowering the intracellular pH

โœ Scribed by Chang W. Song; John C. Lyons; Seymour H. Levitt; Brian Ross

Book ID
103723418
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
111 KB
Volume
21
Category
Article
ISSN
0360-3016

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โœ S.D. Webb; J.A. Sherratt; R.G. Fish ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 199 KB

Measurements of extracellular pH (pHe) in vivo have shown that the microenvironment in tumours is more acidic than in normal tissue. However, both human and animal tumour cells have been shown to have an intracellular pH (pHi) on the alkaline side of neutrality (pH 7.1-7.2). This gives rise to a rev