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Thermosensitive and hydrolysis-sensitive poly(organophosphazenes)

✍ Scribed by Bae Hoon Lee; Young Moo Lee; Youn Soo Sohn; Soo-Chang Song

Book ID
104526569
Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
72 KB
Volume
51
Category
Article
ISSN
0959-8103

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✦ Synopsis

Abstract

The lower critical solution temperature (LCST) properties and hydrolytic behaviour of thermosensitive biodegradable polyphosphazenes with monomethoxy‐poly(ethylene glycol), glycine ethyl ester and depsipeptide ethyl esters substituents have been studied. All the polymers synthesized show LCST properties. The LCSTs of the polymers are affected by the composition of the polymers and increase with the degradation of the polymers in aqueous solution. The higher content of depsipeptide ethyl esters in the polymers accelerates the LCST change and the degradation of the polymers in aqueous solution. Most polymers synthesized have half‐lives of less than 10 days in neutral solution.

Β© 2002 Society of Chemical Industry

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## Abstract **Summary:** After synthesizing both hard poly(organophosphazenes), which acted as strong hydrogels at a temperature below 37 °C, and soft poly(organophosphazenes), which displayed the opposite properties, we blended the polymers. When these polymers were blended at an appropriate ratio