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Thermogenic effects of sibutramine and its metabolites

โœ Scribed by Ian P Connoley; Yong-Ling Liu; Ian Frost; Ian P Reckless; David J Heal; Michael J Stock


Book ID
110004196
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
231 KB
Volume
126
Category
Article
ISSN
0007-1188

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ChemInform Abstract: Synthesis of Sibutr
โœ J. E. JEFFERY; F. KERRIGAN; T. K. MILLER; G. J. SMITH; G. B. TOMETZKI ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 32 KB

Synthesis of Sibutramine, a Novel Cyclobutylalkylamine Useful in the Treatment of Obesity, and Its Major Human Metabolites. -A short and convenient pathway to sibutramine (VII) and some of its demethylated (cf. (V)) and hydroxylated (cf. (XI)) human metabolites is presented. One of the key steps is