ChemInform Abstract: Synthesis of Sibutramine, a Novel Cyclobutylalkylamine Useful in the Treatment of Obesity, and Its Major Human Metabolites.

✍ Scribed by J. E. JEFFERY; F. KERRIGAN; T. K. MILLER; G. J. SMITH; G. B. TOMETZKI

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 32 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199734105

✦ Synopsis

Synthesis of Sibutramine, a Novel Cyclobutylalkylamine Useful in the Treatment of Obesity, and Its Major Human Metabolites. -A short and convenient pathway to sibutramine (VII) and some of its demethylated (cf. (V)) and hydroxylated (cf. (XI)) human metabolites is presented. One of the key steps is an efficient tandem Grignard-reduction reaction. -(JEFFERY,