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Thermodynamics of the G-Quadruplex Formation of Modified Human Telomeric Sequences

✍ Scribed by Li, Yang; Macgregor, Robert B.; Zamiri, Bita

Book ID: 122138575
Publisher: Biophysical Society
Year: 2014
Tongue: English
Weight: 90 KB
Volume: 106
Category: Article
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2013.11.435

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## Abstract Human telomeric DNA consists of tandem repeats of the sequence 5′‐d(TTAGGG)‐3′. Guanine‐rich DNA, such as that seen at telomeres, forms G‐quadruplex secondary structures. Alternative forms of G‐quadruplex structures can have differential effects on activities involved in telomere mainte