Thermodynamics of G-tetraplex formation by telomeric DNAs
β Scribed by Lu, Min; Guo, Qiu; Kallenbach, Neville R.
- Book ID
- 121393166
- Publisher
- American Chemical Society
- Year
- 1993
- Tongue
- English
- Weight
- 976 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0006-2960
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π SIMILAR VOLUMES
Many sequences in genomic DNA are able to form unique tetraplex structures. Such structures are involved in a variety of important cellular processes and are emerging as a new class of therapeutic targets for cancers and other diseases. Screening for molecules targeting the tetraplex structure has b
## Abstract Human telomeric DNA consists of tandem repeats of the sequence 5β²βd(TTAGGG)β3β². Guanineβrich DNA, such as that seen at telomeres, forms Gβquadruplex secondary structures. Alternative forms of Gβquadruplex structures can have differential effects on activities involved in telomere mainte