Thermodynamical properties of simple models of protein-like heteropolymers
β Scribed by Andrzej Sikorski; Piotr Romiszowski
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 2003
- Tongue
- English
- Weight
- 122 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0006-3525
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## Abstract A method has been developed for the rapid construction of protein alphaβcarbon models from a continuous length of metal rod. Selected side groups can be attached, and the scale is continuously variable from 20mm/Γ to 4mm/Γ . At the smaller scales, models are selfβsupporting.
A thermodynamic model describing formation of alpha-helices by peptides and proteins in the absence of specific tertiary interactions has been developed. The model combines free energy terms defining alpha-helix stability in aqueous solution and terms describing immersion of every helix or fragment