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Thermodynamical properties of simple models of protein-like heteropolymers

✍ Scribed by Andrzej Sikorski; Piotr Romiszowski


Publisher
Wiley (John Wiley & Sons)
Year
2003
Tongue
English
Weight
122 KB
Volume
69
Category
Article
ISSN
0006-3525

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## Abstract A method has been developed for the rapid construction of protein alpha‐carbon models from a continuous length of metal rod. Selected side groups can be attached, and the scale is continuously variable from 20mm/Γ… to 4mm/Γ…. At the smaller scales, models are self‐supporting.

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A thermodynamic model describing formation of alpha-helices by peptides and proteins in the absence of specific tertiary interactions has been developed. The model combines free energy terms defining alpha-helix stability in aqueous solution and terms describing immersion of every helix or fragment