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Thermodynamic study of the influence of NADPH on the binding of methotrexate and its metabolites to a mammalian dihydrofolate reductase

✍ Scribed by Gilli, R


Book ID
121900522
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
592 KB
Volume
964
Category
Article
ISSN
0304-4165

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## Abstract Quantum‐mechanical electron density calculations reveal that a significant polarization is induced in the cofactor NADPH (reduced nicotinamide adenine dinucleotide phosphate) on binding to the enzyme dihydrofolate reductase. The calculations indicate that electron density corresponding