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Microcalorimetric study of the binding of methotrexate and its metabolites to thymidylate synthase

✍ Scribed by J. C. Sari; R. Gilli; C. Lopez; C. Briand

Publisher: Springer Netherlands
Year: 1991
Tongue: English
Weight: 287 KB
Volume: 37
Category: Article
ISSN: 0022-5215
DOI: 10.1007/bf01912220

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BACKGROUND. Before this study was conducted, the clinical and therapeutic significance of immunohistochemical evaluation of thymidylate synthase (TS) in patients with gastric carcinoma had not yet been clarified. ## METHODS. TS was immunohistochemically evaluated in 134 gastric carcinomas using a