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Thermodynamic study of the imipramine–insulin interaction

✍ Scribed by José Luis López-Fontán; Victor Mosquera; Carlos Rega; Félix Sarmiento; Malcom N. Jones

Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
169 KB
Volume
31
Category
Article
ISSN
0021-9614

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✦ Synopsis

The interaction of the antidepressant drug imipramine with insulin in aqueous solution at pH = 3.2 (ionic strength I c = 6.5•10 -3 mol • dm -3 ) has been investigated by equilibrium dialysis and microcalorimetry. Imipramine binds to insulin to the extent of ≈(50 to 60) imipramine molecules per insulin molecule in the temperature range T = (283.15 to 308.15) K. The binding data have been used to obtain the Gibbs energy per imipramine molecule bound G ν using the Wyman binding potential approach. The enthalpy of the interaction is small and exothermic following a sigmoidal curve as a function of binding, and G ν is dominated by a large entropy increase on binding which is of similar magnitude to the non-specific hydrophobic binding of several other amphipathic ligands with globular proteins.

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Kinetics and thermodynamic parameters of
Kinetics and thermodynamic parameters of the thermal decomposition of imipramine hydrochloride and trimipramine maleate
✍ Rafie H. Abu-Eittah; Laila T. Kamel 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 182 KB

## Abstract Thermal decomposition of imipramine hydrochloride and trimipramine maleate has been investigated isothermally and nonisothermally. The kinetic parameters, namely the activation energy __E__~a~ and the Arrhenius preexponential term __A__, were calculated. Applying the theory of activated