Thermodynamic Roles of Basic Amino Acids in Statherin Recognition of Hydroxyapatite †
✍ Scribed by Goobes, Rivka; Goobes, Gil; Shaw, Wendy J.; Drobny, Gary P.; Campbell, Charles T.; Stayton, Patrick S.
- Book ID
- 120464617
- Publisher
- American Chemical Society
- Year
- 2007
- Tongue
- English
- Weight
- 204 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0006-2960
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## Abstract Statistical analysis of structures from the PBD has been used to examine the role that the aromatic amino acids play in protein–nucleic acid recognition. In protein–DNA complexes, the residues Phe and His are found to bind selectively to the DNA chain—Phe to A and T, and His to T and G.
The elution behavior from hydroxyapatite columns of the modification products of seven basic and three acidic proteins has been investigated. Three classes of NH2 derivatives were prepared. These consisted of (1) replacement by a guanidyl group with no change in charge; (2) blocking with loss of cha