Thermodynamic and structural effects of propranolol on DPPC liposomes

✍ Scribed by G. Albertini; C. Donati; R.S. Phadke; M.G. Ponzi Bossi; F. Rustichelli

• Publisher: Elsevier Science
• Year: 1990
• Tongue: English
• Weight: 427 KB
• Volume: 55
• Category: Article
• ISSN: 0009-3084
• DOI: 10.1016/0009-3084(90)90171-m

✦ Synopsis

Some thermodynamic and structural aspects of propranoloI-DPPC liposomes interaction were investigated by DSC and X-ray diffraction: the lamellar arrangement of the lipid matrix remains intact even at high concentrations of the drug (until I:l drug/ lipid molar ratio). However, the bilayer thickness increases significantly and the chains become perpendicular to the lamellar planes, for increasing drug content. At still higher propranolol concentrations a hexagonal phase occurs followed by a lamellar phase, in which the liposomes are destroyed. Moreover, the presence of propranolol has been found to impart fluidity to the lipid matrix.