## Abstract ## Background Dry powder dispersion devices offer potential for delivering therapeutic macromolecules to the pulmonary epithelia. Previously, freezeβdrying (lyophilisation) has been the accepted method for preparing dried formulations of proteins and nonβviral gene vectors despite the
Structural effects caused by spray- and freeze-drying of liposomes and bilayer disks
β Scribed by Per Wessman; Katarina Edwards; Denny Mahlin
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 346 KB
- Volume
- 99
- Category
- Article
- ISSN
- 0022-3549
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Biological membranes immobilized in chromatographic gel beads constitute a multifunctional affinity matrix. Membrane protein-solute interactions and drug partitioning into the lipid bilayers can conveniently be studied. By the use of confocal laser-scanning microscopy (CLSM) the distribution of immo
The effects of wetting liquid and initial freezing conditions on the pore volume and pore size distribution of freeze-dried microcrystalline cellulose (MCC) pellets were studied with mercury porosimetry. Freeze-drying was applied after extrusion/spheronization using two wetting liquids (water and wa