Thermal .pi.-route rearrangement of 4-cycloheptene-1-methyl acetate
β Scribed by Thies, Richard W.; Schick, Lawrence E.
- Book ID
- 126904576
- Publisher
- American Chemical Society
- Year
- 1974
- Tongue
- English
- Weight
- 644 KB
- Volume
- 96
- Category
- Article
- ISSN
- 0002-7863
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4βMethylβ1,2,5βhexatriene (13) has been prepared and subjected to gasβphase pyrolysis. Above 220Β°C, 13 rearranges reversibly to both __trans__β5βheptenβ1βyne (14) and its __cis__βisomer 15. Formation of 14 is faster than that of 15. These isomerisations are accompanied by a slower irreversible rearr
A Convenient Synthesis of 2-Fluoro-Ξ±-methyl[1,1'-biphenyl]-4-acetic Acid via Rearrangement of Aryl Ketones. -For the synthesis of (Β±)-flurbiprofen (VIII), a potent antiinflammatory agent, 4 rearrangement methods are employed. The lead tetraacetate mediated 1,2-aryl shift of (V) is quite successful