Thermal analysis of amorphous phase in a pharmaceutical drug
β Scribed by N. Fagegaltier; A. Lamure; C. Lacabanne; A. Caron; H. Mifsud; M. Bauer
- Book ID
- 105424827
- Publisher
- Springer Netherlands
- Year
- 1997
- Tongue
- English
- Weight
- 302 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0022-5215
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π SIMILAR VOLUMES
Two crystalline forms and the amorphous state of irbesartan, a pharmaceutical drug chosen as a model, were analyzed by Thermally Stimulated Current (TSC) spectroscopy, a powerful technique currently used in polymer science to investigate the molecular dynamics of heterogeneous and complex materials.
In recent years there has been growing interest in advancing amorphous pharmaceuticals as an approach for achieving adequate solubility. Due to difficulties in the experimental measurement of solubility, a reliable estimate of the solubility enhancement ratio of an amorphous form of a drug relative