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Therapy-related MDS: the importance of repeating cytogenetics and immunophenotyping in “relapsed” AML

✍ Scribed by Prashant Sharma, Meet Kumar, Meena Lall, Lalit Kumar…


Book ID
120960262
Publisher
Springer-Verlag
Year
2013
Tongue
English
Weight
300 KB
Volume
6
Category
Article
ISSN
1865-5785

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## Abstract Activating mutations of the __PTPN11__ gene encoding the SHP2 tyrosine phosphatase is the most common genetic abnormality in juvenile myelomonocytic leukemia and is sporadically observed in myelodysplasia (MDS) and acute myeloid leukemia (AML). An unselected series of 140 patients with