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Amplification or duplication of chromosome band 21q22 with multiple copies of the AML1 gene and mutation of the TP53 gene in therapy-related MDS and AML

✍ Scribed by Andersen, M K; Christiansen, D H; Pedersen-Bjergaard, J


Book ID
110056135
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
118 KB
Volume
19
Category
Article
ISSN
0887-6924

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Duplication or amplification of chromoso
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## Abstract Gene amplification is a rare phenomenon in acute leukemia, but recently amplification of specific chromosome bands containing genes rearranged in leukemia‐specific balanced chromosome translocations has been reported in a few cases. We detected duplication or amplification of chromosome

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## Abstract Activating mutations of the __PTPN11__ gene encoding the SHP2 tyrosine phosphatase is the most common genetic abnormality in juvenile myelomonocytic leukemia and is sporadically observed in myelodysplasia (MDS) and acute myeloid leukemia (AML). An unselected series of 140 patients with