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Therapeutic targeting of the insulin-like growth factor-I receptor (IGF-IR) plus oxaliplatin decreases hepatic growth of human colon cancer

✍ Scribed by T. W. Bauer; M. F. McCarty; J. Wey; A. Belcheva; R. J. Somcio; F. Fan; W. Liu; R. Singh; L. M. Ellis


Book ID
110547678
Publisher
Springer
Year
2004
Tongue
English
Weight
160 KB
Volume
11
Category
Article
ISSN
1068-9265

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## Abstract ## BACKGROUND High concentrations of insulin‐like growth factor (IGF)‐I and IGF‐II have been demonstrated in human colonic adenocarcinomas and exert mitogenic effects through paracrine/autocrine interactions with the IGF‐I receptor (IGF‐IR). However, definitive studies of IGF‐IR expres