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Luteolin decreases IGF-II production and downregulates insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells

✍ Scribed by Lim, Do Y. (author);Cho, Han J. (author);Kim, Jongdai (author);Nho, Chu W. (author);Lee, Ki W. (author);Park, Jung H.Y. (author)


Book ID
115009032
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
392 KB
Volume
12
Category
Article
ISSN
1471-230X

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## Abstract The HT‐29 human colon cancer cell line has previously been shown to secrete high amounts of insulin‐like growth factor II (IGF‐II). The recent demonstration that soluble IGF‐II/ mannose 6‐phosphate receptor was present in fetal serum prompted us to search for a release of type‐II IGF re