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Therapeutic prospects for p73 and p63: Rising from the shadow of p53

โœ Scribed by Anna Vilgelm; Wael El-Rifai; Alexander Zaika


Book ID
116413285
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
877 KB
Volume
11
Category
Article
ISSN
1368-7646

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p63 and p73 are functionally and structurally related to the tumor suppressor p53. However, their own role in tumor suppression is unclear. Given the p53-like properties of p63 and p73, we tested whether they are involved in tumor suppression by aging mice heterozygous for mutations in all p53 famil