Therapeutic liver repopulation for phenylketonuria
โ Scribed by Cary O. Harding; K. M. Gibson
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 153 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0141-8955
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๐ SIMILAR VOLUMES
Liver-directed gene therapy is appropriate for many conditions. Recent work established that liver repopulation with transplanted cells can be effective in treating genetic disorders. Although hepatocytes express therapeutic genes with considerable efยฎciency, correction of genetic disorders is const
To examine the distribution of intrasplenically transplanted hepatocytes, we used HBsAg-producing 6 7 HBV transgenic hepatocytes or cells labeled with '"In. Most hepatocytes translocated to the liver (55% f 7%; mean k S.D.); the spleen retained a smaller fraction (15% \* 3%); and some transplanted c