Liver-directed gene therapy is appropriate for many conditions. Recent work established that liver repopulation with transplanted cells can be effective in treating genetic disorders. Although hepatocytes express therapeutic genes with considerable efยฎciency, correction of genetic disorders is const
Hepatocyte transplantation for total liver repopulation
โ Scribed by Mizuguchi, Toru ;Mitaka, Toshihiro ;Katsuramaki, Tadashi ;Hirata, Koichi
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 130 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0944-1166
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Hepatocyte transplantation (HT) is an attractive therapeutic modality for liver disease as an alternative for liver organ transplantation. Primary fresh hepatocytes (FHs) are the exclusive cell source that has been used for clinical HT. However, the use of FHs is limited due to a shortage of donor c
The majority of patients with acute liver failure (ALF) die waiting for orthotopic liver transplantation (OLT). No other treatment modality is shown to improve survival. This study was conducted to assess the safety and feasibility of hepatocyte transplantation (HT) and subsequent engraftment and fu