Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis
โ Scribed by Harald H. Hofstetter; Saleh M. Ibrahim; Dirk Koczan; Niels Kruse; Andreas Weishaupt; Klaus V. Toyka; Ralf Gold
- Book ID
- 113526916
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 210 KB
- Volume
- 237
- Category
- Article
- ISSN
- 0008-8749
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We report on the effect of antibody-mediated neutralization of interleukin (IL)-17A in a non-human primate experimental autoimmune encephalomyelitis (EAE) model induced with recombinant human myelin oligodendrocyte glycoprotein (rhMOG). We tested a human-anti-human IL-17A-antibody in two doses (3 an
## Abstract Nitrosative stress has been implicated in the pathophysiology of several CNS disorders, including multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). We have recently shown that protein nitrosothiols (PrSNOs) accumulate in the brain of MS patien