Therapeutic effect of Oren-gedoku-to extract on stress-induced acute gastric mucosal lesions in rats

✍ Scribed by Yoshiji Ohta; Takashi Kobayashi; Keiji Nishida; Minoru Nagata; Isao Ishiguro

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 61 KB
• Volume: 13
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(199911)13:7<588::aid-ptr505>3.0.co;2-p

✦ Synopsis

Oral administration of Oren-gedoku-to extract (TJ-15), a traditional Chinese herbal medicine for the therapy of gastric ulcers and gastritis, dose-dependently prevented the progression of acute gastric mucosal lesions in rats with water immersion restraint (WIR) stress. The preventive effect of TJ-15 on the lesion progression was stronger than that of Saiko-keishi-to extract (TJ-10) or Shigyaku-san extract (TJ-35), each of which is a traditional Chinese herbal medicine for the therapy of gastric ulcers and gastritis, when compared on the basis of a single dosage of each medicine for adults. This TJ-15 administration attenuated increases in gastric mucosal lipid peroxide concentration and xanthine oxidase and myeloperoxidase activities with the gastric mucosal lesion progression and recovered the decreased gastric mucosal non-protein SH concentration found at a progressed stage of the gastric mucosal lesions. These results indicate that TJ-15 exerts a therapeutic effect on WIR stress-induced acute gastric lesions in rats more strongly than TJ-10 or TJ-35, and suggest that the therapeutic effect of TJ-15 could be due to its preventive actions on lipid peroxidation and sulphydryl oxidation via oxygen free radicals generated by the xanthine-XO system and infiltrated neutrophils in the gastric mucosa and on neutrophil infiltration into the tissue.