Contribution of the antilipid peroxidative action of Dai-saiko-to extract to its preventive effect on carbon tetrachloride-induced acute liver injury in rats
✍ Scribed by Yoshiji Ohta; Emi Sasaki; Keiji Nishida; Mutsumi Kongo; Takahiro Hayashi; Minoru Nagata; Isao Ishiguro
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 143 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0951-418X
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✦ Synopsis
Post-oral administration of Dai-saiko-to extract (TJ-8), a traditional herbal medicine, ameliorated acute liver injury in rats intoxicated with carbon tetrachloride (CCl 4 ). This TJ-8 administration inhibited an increase in lipid peroxide contents in the liver homogenate and microsomal fraction and a decrease in glucose-6-phosphatase activity in the liver microsomal fraction, an index of lipid peroxidation-mediated damage in liver microsomes, during the progression and recovery of the liver injury. These results indicate that the antilipid peroxidative action of TJ-8 contributes to its preventive effect on CCl 4 -induced acute liver injury in rats.