Nature has long used nucleic acid aptamers and enzymes for regulatory activities, such as the recently discovered “riboswitches” involved in gene expression. The existence of a large array of natural and artificial functional nucleic acids has generated tremendous enthusiasm and new opportunities fo
✦ LIBER ✦
Therapeutic applications of ribozymes and riboswitches
✍ Scribed by Jérôme Mulhbacher; Patrick St-Pierre; Daniel A Lafontaine
- Book ID
- 116383875
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 225 KB
- Volume
- 10
- Category
- Article
- ISSN
- 1471-4892
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Genome-sequencing projects are proceeding at a rapid pace and determining the function of open reading frames is the next great challenge. Ribozymes with site-specific cleaving activity could aid greatly in this process. High-throughput screening methods to identify optimal target sites for ribozyme