Therapeutic antibody engineering: Current and future advances driving the strongest growth area in the pharmaceutical industry

✍ Scribed by William Strohl, Lila Strohl

• Publisher: Woodhead Publishing
• Year: 2012
• Tongue: English
• Leaves: 693
• Series: Woodhead Publishing Series in Biomedicine
• Edition: 1
• Category: Library

✦ Synopsis

The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas.This book examines all aspects of engineering monoclonal antibodies to make them more competitive and looks at ways that the various genetic engineering approaches will affect candidates of the future. The authors go beyond the standard engineering issues (ADCC, CDC, half life engineering, etc.) that are covered by most books and delve into structure function relationships that will help to evolve new antibody structures beyond those already in clinical trials. Chapters discuss how current and future genetic engineering of cell lines will pave the way for much higher productivity, allowing for an overall decrease in cost of goods.