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✦   LIBER   ✦

Theory and generalization of monte carlo models of the BOLD signal source

✍ Scribed by John Martindale; Aneurin J. Kennerley; David Johnston; Ying Zheng; John E. Mayhew

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
685 KB
Volume
59
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

The dependency of the blood oxygenation level dependent (BOLD) signal on underlying hemodynamics is not well understood. Building a forward biophysical model of this relationship is important for the quantitative estimation of the hemodynamic changes and neural activity underlying functional magnetic resonance imaging (fMRI) signals. We have developed a general model of the BOLD signal which can model both intra‐ and extravascular signals for an arbitrary tissue model across a wide range of imaging parameters. The model of the BOLD signal was instantiated as a look‐up‐table (LuT), and was verified against concurrent fMRI and optical imaging measurements of activation induced hemodynamics. Magn Reson Med, 2008. Β© 2008 Wiley‐Liss, Inc.

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