Theoretical study on the alkylation and protonation of the nucleic acid bases
✍ Scribed by Stanislav Miertš; Magdaléna Trebatická
- Book ID
- 108360177
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 399 KB
- Volume
- 108
- Category
- Article
- ISSN
- 0022-5193
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📜 SIMILAR VOLUMES
Stacking of aromatic amino acids tryptophan (Trp), tyrosine (Tyr), phenylalanine (Phe), and histidine (His) with bases and base pairs of nucleic acids has been studied. Stacking energies of the amino acid-base (or base pair) complexes have been calculated by second-order perturbation theory. Our res
Gradient-corrected density functional computations with triplezeta-type basis sets were performed to determine the preferred protonation site and the absolute gas-phase proton affinities of the most stable tautomer of the Ž . Ž . Ž . Ž . DNA bases thymine T , cytosine C , adenine A , and guanine G .
With a view to understanding the role of hydrogen bonds in the recognition of nucleic acids by proteins, hydrogen bonding between the bases and base pairs of nucleic acids and the amino acids (Am, Gln, Asp and Glu, and charged residues Arg+, Glu-, and Asp-) has been studied by a second-order perturb