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Theoretical studies on conformational preferences of modified nucleic acid base N6-(N-glycylcarbonyl) adenine

✍ Scribed by Ravindra Tewari


Book ID
104582112
Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
714 KB
Volume
31
Category
Article
ISSN
0020-7608

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πŸ“œ SIMILAR VOLUMES


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✍ Ravindra Tewari πŸ“‚ Article πŸ“… 1995 πŸ› Elsevier Science 🌐 English βš– 361 KB

Protonation-induced conformational changes are studied in the hypermodified nucleic acid base N6-(N-glycylcarbonyl) adenine, gc6Ade, using the quantum chemical perturbative configuration interaction using localised orbitals method. Protonation at the N(7) position of adenine in gc6Ade induces reorie

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The influence of protonation at N 1 on the conformational preferences Ε½ . 6 Ε½ . of the N 6 substituent in the modified nucleic acid base N -N-glycylcarbonyl adenine, gc 6 Ade, was investigated by the quantum chemical perturbative configuration interaction Ε½ . using localized orbitals PCILO method.

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With a view to understanding the role of hydrogen bonds in the recognition of nucleic acids by proteins, hydrogen bonding between the bases and base pairs of nucleic acids and the amino acids (Am, Gln, Asp and Glu, and charged residues Arg+, Glu-, and Asp-) has been studied by a second-order perturb

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Stacking of aromatic amino acids tryptophan (Trp), tyrosine (Tyr), phenylalanine (Phe), and histidine (His) with bases and base pairs of nucleic acids has been studied. Stacking energies of the amino acid-base (or base pair) complexes have been calculated by second-order perturbation theory. Our res