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Theoretical studies of the reduction reaction of the anti-tumor drug FR900482

โœ Scribed by Anne-Marie Sapse; Duli C. Jain

Book ID
106239740
Publisher
Springer-Verlag
Year
2006
Tongue
English
Weight
151 KB
Volume
13
Category
Article
ISSN
1610-2940

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Intramolecular reductive amination is utilized as a key &membered ring-forming cyclization reaction to construct the novel bicyclic hydroxylamine hemi-ketal ring system of FR900482. The recently discovered anti-tumor antibiotic FR-900482 (1) was obtained from the fermentation harvest of Streptomyce