Theoretical studies on the acid hydrolys
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Ikchoon Lee; Chang Kon Kim; Byung Choon Lee
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Article
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1987
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John Wiley and Sons
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English
β 499 KB
The mechanism of the A2 acid hydrolysis of methyl carbamate was investigated using MNDO method. The reaction was found to proceed in two steps: (1) the rate-determining nucleophilic attack of water on the carbonyl carbon of the N-protonated tautomer involving the tetrahedral TS; and (2) the fast sub