Theoretical analysis of the binding of salicylate by human serum albumin: The relationship between free and bound drug and therapeutic levels
β Scribed by W. D. Wosilait
- Publisher
- Springer
- Year
- 1976
- Tongue
- English
- Weight
- 578 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0031-6970
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The binding of salicylate ion to human serum albumin (HSA) was studied in 100 mM potassium phosphate buffer (pH 7.4, 25 degrees C), using equilibrium dialysis and fluorescence titration methods. The protein samples tested were (a) dialyzed human plasma and (b) a commercial preparation of HSA, essent
Correlation between binding parameters of 6 benzodiazepines to free human serum albumin (HSA) and chromatographic retention parameters on the HSA stationary phase (HSA-SP) was better than the similar correlation with alpha-1-acid glycoprotein (AGP). Still better correlation was obtained between bind