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Relationships between binding of benzodiazepines to alpha-1-acid glycoprotein and human serum albumin and their retention on the protein and octadecylsilane columns

✍ Scribed by Nina Sadlej-Sosnowska

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 201 KB
Volume: 9
Category: Article
ISSN: 0269-3879
DOI: 10.1002/bmc.1130090308

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✦ Synopsis

Correlation between binding parameters of 6 benzodiazepines to free human serum albumin (HSA) and chromatographic retention parameters on the HSA stationary phase (HSA-SP) was better than the similar correlation with alpha-1-acid glycoprotein (AGP). Still better correlation was obtained between binding to both proteins and retention on an octadecylsilane (ODS) column. For 12 benzodiazepines the correlations of the retention parameters on both protein columns with the retention on the ODS column were additionally investigated. In the case of HSA this correlation was good.

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