Theophylline-induced changes in the activity of carnitine palmitoyltransferase in rat cardiac tissues

✍ Scribed by A.S Alhomida

• Publisher: Elsevier Science
• Year: 2000
• Tongue: English
• Weight: 136 KB
• Volume: 145
• Category: Article
• ISSN: 0300-483X
• DOI: 10.1016/s0300-483x(00)00153-0

✦ Synopsis

This study is conducted to investigate the influence of oral theophylline administration (100 mg/kg bw per day) on the activity of carnitine palmitoyltransferase (CPT) in cardiac tissues of rats for 5-week interval treatments. Results showed significant increase in the activity of CPT was observed in cardiac tissues of theophylline-treated groups as compared to either control or placebo groups. Moreover, the results showed positive correlations between the cardiac concentrations of long-chain acylcarnitine (LC) and the activity of CPT and between plasma concentrations of LC and the cardiac concentrations of LC (PB 0.01), respectively. The observed changes in activity of cardiac CPT might be due to the result from theophylline-enhanced decrease the sensitivity of CPT to inhibition by malonyl-CoA and/or from theophylline-enhanced mobilization of lipid from adipose tissues which consequently stimulated an increased carnitine transport into the tissues to form palmitoylcarnitine groups for subsequent b-oxidation inside the mitochondria. Thus, these accumulations of acylcarnitine groups in mitochondria may increase the catalytic action of CPT.