Investigation of the effect of theophylline administration on total, free, short-chain acyl and long-chain acyl carnitine distributions in rat renal tissues
✍ Scribed by A. S. Alhomida
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 145 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0263-6484
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✦ Synopsis
This study is conducted to investigate the eect of oral theophylline administration on total (TC), free (FC), short-(SC), long-chain acyl (LC), acyl (AC) carnitine distributions as well as the ratio of acyl to free carnitine (AC/FC) in rat renal tissues. Theophylline was administrated at 100 mg kg 71 body weight day 71 , and eects were monitored after a treatment period that lasted between 1 week and 5 weeks. The results indicated that theophylline administration leads to signi®cantly higher concentrations of TC, FC, SC, L and AC in renal tissues as compared to those of control and placebo groups (P 5 0 . 001). Moreover, the ratio of AC/FC was signi®cantly increased (P 5 0 . 001) as compared to either control or placebo groups. These changes may result from theophylline-enhanced mobilization of lipids from adipose tissues, which consequently stimulates an increased carnitine transport into the renal tissues to form acylcarnitines for subsequent b-oxidation inside the renal mitochondria.