## Abstract Theophyllineโ7โacetic acid (T7AA) was administered intravenously to rabbits so that its distribution and rate of elimination could be ascertained. The analytical techniques used were liquid scintillation counting (^14^C) and high pressure liquid chromatography. T7AA was eliminated rapid
Theophylline absorption and disposition in rabbits: Oral, intravenous, and concentration-dependent kinetic studies
โ Scribed by Adnan El-Yazigi; Ronald J. Sawchuk
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 587 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0022-3549
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๐ SIMILAR VOLUMES
The absorption and disposition of methotrexate (MTX) in the plasma, synovial fluid (SF), skin, and muscle tissue were studied following administration of a topical MTX gel in rabbits and rats. In rabbits, MTX concentrations in the plasma increased steadily toward the peak (5.9 +/- 2.8 ng mL-1) which
Blood nitrite and nitrate concentrations were measured after oral and intravenous administration of glyceryl trinitrate at 1.0 mg./Kg. in rabbits. Nitrate and nitrite blood concentrations attained peak concentrations in 90-1 20 min. after oral ad-
## Abstract A sensitive and specific method for the estimation of theophyllineโ7โacetic acid in plasma by high performance liquid chromatography is described. Acidified plasma is extracted with chloroformโ__n__โbutanol (85: 15), back extracted with phosphate buffer (0.5 moll^โ1^, pH 6.5), and final