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Theobromine metabolism and pharmacokinetics in pregnant and nonpregnant Sprague-Dawley rats

✍ Scribed by Carol A. Shively; Stanley M. Tarka Jr.

Book ID
113206177
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
492 KB
Volume
67
Category
Article
ISSN
0041-008X

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The pharmacokinetics of metoclopramide was studied in chronically instrumented pregnant and nonpregnant sheep. Metoclopramide was administered to the ewe by intravenous bolus injections (on a crossover basis) of 10, 20, and 40 mg, with an additional 80-mg dose to the nonpregnant animals. Transfer of