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Monocrotaline Metabolism and Distribution in Fisher 344 and Sprague-Dawley Rats

✍ Scribed by M.J Reid; M.W Lamé; D Morin; D.W Wilson; H.J Segall

Book ID
117485429
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
460 KB
Volume
117
Category
Article
ISSN
1096-4959

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The metabolism and disposition of [2,3-'4C]acrolein was studied in Sprague-Dawley rats after oral or intravenous dosing. Four groups of ten rats (five male and five female) were dosed with radiolabeled acrolein intravenously at 2.5 mg kg-' (Group 2), orally by gavage at 2.5 mg kg-I, either as a sing