Intracerebral infection of susceptible mouse strains with Theiler's murine encephalomyelitis virus (TMEV) results in an immune-mediated demyelinating disease (TMEV-IDD) similar to human multiple sclerosis (MS). Although the etiology of MS remains unknown, a role of an infectious agent has been impli
Theiler's virus encephalomyelitis is unaffected by treatment with myelin components
β Scribed by Walter Lang; Clayton Wiley; Peter Lampert
- Book ID
- 119506550
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 264 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0165-5728
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Theiler's murine encephalomyelitis virus (TMEV) is known to interact with cells of the central nervous system (CNS). Here we report that, interestingly, it is a potent inductor of interleukin-6 (IL-6) in the CNS of infected animals and in pure cultures of astrocytes. Maximal IL-6 gene transcription
Theiler's murine encephalomyelitis virus (TMEV) infection in the central nervous system (CNS) induces a demyelinating disease similar to human multiple sclerosis. TMEV infection results in activation of various chemokine and cytokine genes that are important in the initiation of an inflammatory resp