TheBlocus (MHC) in the chicken: Association with the fate of RSV-induced tumors
β Scribed by Walter M. Collins; W. Elwood Briles; Robert M. Zsigray; William R. Dunlop; Allan C. Corbett; Kathy K. Clark; James L. Marks; Timothy P. McGrail
- Publisher
- Springer-Verlag
- Year
- 1977
- Tongue
- English
- Weight
- 689 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0093-7711
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Lymphocytes from chickens homozygous (B2B2) at the major histocompatibility complex (MHC) were tested for cytotoxic against five types of target chicken embryo fibroblasts (CEF). Lymphocytes from B2B2 chickens bearing RSV-induced tumors lysed in vitro targets of B2B2 and B5B5 RSV-infected CEF and B5
We report that the cloned DNA harboring the long terminal repeat (LTR), v-src, LTR proviral structure is tumorigenic in chickens of the Prague congenic lines. The growth rate of these tumors is by far the highest in the recombinant CC.R1 line, the B haplotype of which is composed of the B-F/L 4 and