Tumor induction by the LTR, v-src, LTR DNA in four B (MHC) congenic lines of chickens
✍ Scribed by Jan Svoboda; Jiří Plachý; Jiří Hejnar; Ivan Karakoz; Ramareddy V. Guntaka; Josef Geryk
- Publisher
- Springer-Verlag
- Year
- 1992
- Tongue
- English
- Weight
- 1011 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0093-7711
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✦ Synopsis
We report that the cloned DNA harboring the long terminal repeat (LTR), v-src, LTR proviral structure is tumorigenic in chickens of the Prague congenic lines. The growth rate of these tumors is by far the highest in the recombinant CC.R1 line, the B haplotype of which is composed of the B-F/L 4 and B-G 12 subregions originating from different naturally occurring haplotypes. Some of the tumors induced by the LTR, v-src, LTR DNA are repeatedly transplantable in syngeneic chickens, maintain unaltered provirus, and express v-src mRNA. Differences in the response to challenge with Rous sarcoma virus (RSV) and LTR, v-src, LTR DNA on a given experimental model are compared and possible involvement of an interaction between B-F/L and B-G region genes is considered. Regression of the LTR, v-src, LTR DNAinduced tumors did not prevent the formation and growth of tumors induced subsequently by RSV.