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The βI/βIII-tubulin isoforms and their complexes with antimitotic agents : Docking and molecular dynamics studies

✍ Scribed by Matteo Magnani; Francesco Ortuso; Simonetta Soro; Stefano Alcaro; Anna Tramontano; Maurizio Botta


Book ID
111311549
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
673 KB
Volume
273
Category
Article
ISSN
1432-1327

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The formation of complexes and the mode of binding to macrocyclic host molecules (a-and bcyclodextrins, CDs) of the nootropic drug CI-844 (3-phenoxypyridine sulphate, Warner-Lambert/Parke-Davis) were studied using NMR techniques (T-ROESY) complemented by molecular dynamics (MD) protocols which allow