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High field NMR techniques, molecular modelling and molecular dynamics simulations in the study of the inclusion complex of the cognition activator (±)-1-(4-methoxybenzoyl)-5-oxo-2-pyrrolidinepropanoic acid (CI-933) with β-cyclodextrin

✍ Scribed by Maria E. Amato; Giuseppe M. Lombardo; Giuseppe C. Pappalardo; Giuseppe Scarlata


Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
693 KB
Volume
350
Category
Article
ISSN
0022-2860

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✍ Maria E. Amato; Giuseppe C. Pappalardo; Bruno Perly 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 617 KB

## Abstract The structural features of the inclusion complexes of cyclodextrins (CDs) with the chiral cognition activator drug (±)9‐[(phenylmethyl)amino]‐1,2,3,4‐tetrahydroacridin‐1‐ol maleate (suronacrine maleate, HP‐128) were studied using both high‐resolution ^1^H NMR spectroscopy and molecular

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The formation of complexes and the mode of binding to macrocyclic host molecules (a-and bcyclodextrins, CDs) of the nootropic drug CI-844 (3-phenoxypyridine sulphate, Warner-Lambert/Parke-Davis) were studied using NMR techniques (T-ROESY) complemented by molecular dynamics (MD) protocols which allow