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The β2subunit of human placenta hexosaminidase (Hex) A and B is a non-random association of the two polypeptides αaand βb

✍ Scribed by B. O'Dowd; D. Mahuran; J. A. Lowden


Book ID
112484364
Publisher
Springer
Year
1984
Tongue
English
Weight
440 KB
Volume
4
Category
Article
ISSN
0144-8463

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Mutations in the HEXA gene, encoding the alpha-subunit of beta-hexosaminidase A (Hex A), that abolish Hex A enzyme activity cause Tay-Sachs disease (TSD), the fatal infantile form of G(M2) gangliosidosis, Type 1. Less severe, subacute (juvenile-onset) and chronic (adult-onset) variants are character